Construction of Furan Derivatives with a Trifluoromethyl Stereogenic Center: Enantioselective Friedel-Crafts Alkylations via Formal Trienamine Catalysis.
نویسندگان
چکیده
An asymmetric Friedel-Crafts alkylation reaction of 2-furfuryl ketones with β-trifluoromethyl enones has been developed via formal trienamine catalysis of a bifunctional primary amine-thiourea substance derived from L-tert-leucine, delivering the furan derivatives incorporating a stereogenic trifluoromethyl (CF3) group in good to high yields with excellent enantioselectivity.
منابع مشابه
A review of new developments in the Friedel–Crafts alkylation – From green chemistry to asymmetric catalysis
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 81 20 شماره
صفحات -
تاریخ انتشار 2016